BS3 (Sulfo-DSS) is a homobifunctional amine-specific crosslinking reagent based on NHS-ester reactive groups for selective conjugation of primary amines.
BS3 contains two sulfo-NHS ester groups at both ends of a 8-carbon spacer.
The sulfo moieties provide excellent water solubility and allows BS3 to be used in acqueous buffer solutions without the need of organic solvents that may cause protein perturbation.


Water-soluble, non-cleavable and membrane impermeable
Readily reacts with primary amines in the pH range 7-9

Bis(sulfosuccinimidyl) suberate sodium salt, Suberic acid bis(3-sulfo-N-hydroxysuccinimide ester) sodium salt


572.43 g/mol

138-139 °C

Desiccated at -20 °C under Argon. Product is shipped at ambient temperature

≥ 95%


Soluble in cold and hot water

Order guide

Order-No.Unit SizePrice
H200N,002525 mg60.00
H200N,005050 mg105.00
H200N,0100100 mg190.00
H200N,0250250 mg320.00

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