Sulfo-SMCC is a heterobifunctional amine to sulfhydryl crosslinking reagent.
Sulfo-SMCC contains one sulfo-NHS ester group and a maleimide reactive group at each end of a cyclohexyl spacer.
The NHS ester groups readily react towards primary amines at pH 7-9.
The maleimide group reacts towards sulfhydryl (or thiol) groups at pH 6.5-7.5.
The sulfo moieties provide excellent water solubility and allows Sulfo-SMCC to be used in acqueous buffer solutions without the need of organic solvents that may cause protein perturbation.


Non-cleavable, membrane impermeable and water-soluble heterobifunctional reagent

3-sulfo-N-hydroxysuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate sodium salt


436.37 g/mol

No data available

Desiccated at -20 °C under Argon. Product is shipped at ambient temperature

≥ 95%


Soluble in cold and hot water

Order guide

Order-No.Unit SizePrice
E130W,001010 mg50.00
E130W,002525 mg90.00
E130W,005050 mg150.00
E130W,0100100 mg270.00

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