SIA is a heterobifunctional amine to sulfhydryl crosslinking reagent.
SIA contains one NHS ester group and a iodoacetyl reactive group at each end of a short 1.5 angstroms spacer.
The NHS ester groups readily react towards primary amines at pH 7-9.
The iodoacetyl group reacts towards sulfhydryl (or thiol) groups at pH > 7.5.
SIA is not water soluble and must be dissolved in an organic solvent such as DMSO or DMF prior to use.


Water-insoluble and non cleavable

N-hydroxysuccinimidyl iodoacetate


283.02 g/mol

144-145 °C

Desiccated at -20 °C under Argon. Product is shipped at ambient temperature

≥ 99%


DMSO, DMF. Water insoluble

Order guide

Order-No.Unit SizePrice
E060N,005050 mg55.00
E060N,0100100 mg100.00

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