SATA is a short-chain (2.8 angstroms spacer arm) reagent for covalent modification of primary amines with a protected sulfhydryl, simulating a crosslinking reagent.
SATA reacts with primary amines at pH 7-9 and the resulting modified molecule contains a protected reactive group, which can be deprotected to give the reactive thiol by treatment with hydroxylamine-HCl.
Before deprotection, the modified molecule can be stored indefinitely.
Sulfhydryl groups are important in protein chemistry modification, but are not always present in the molecule of interest.


Non cleavable, amine to thiol modification reagent

N-Succinimidyl (acetylthio)acetate


231.20 g/mol

90-93 °C

Desiccated at -20 °C under Argon. Product is shipped at ambient temperature

≥ 99%


DMSO, DMF. Very slightly water soluble

Order guide

Order-No.Unit SizePrice
E050N,005050 mg60.00
E050N,0100100 mg105.00
E050N,0250250 mg190.00

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