GMBS is a heterobifunctional amine to sulfhydryl crosslinking reagent.
GMBS contains one NHS ester group and a maleimide reactive group at each end of an aliphatic 5-atom spacer.
The NHS ester groups readily react towards primary amines at pH 7-9.
The maleimide group reacts towards sulfhydryl (or thiol) groups at pH 6.5-7.5.
GMBS is not water soluble and must be dissolved in an organic solvent such as DMSO or DMF prior to use.


Water-insoluble and non cleavable

N-Succinimidyl 4-maleimidobutyrate,4-Maleimidobutyric acid N-succinimidyl ester, N-(γ-maleimidobutyryloxy)-N-hydroxysuccinimide ester


280.20 g/mol

123-125 °C

Desiccated at -20 °C under Argon. Product is shipped at ambient temperature

≥ 98%


DMSO, DMF. Water insoluble

Order guide

Order-No.Unit SizePrice
E011W,002525 mg55.00
E011W,005050 mg95.00
E011W,0100100 mg170.00

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